- "I hold it, that a little rebellion, now and then, is a good thing, and as necessary in the political world as storms in the physical."
- — Thomas Jefferson
Thomas Jefferson is the 3rd President and 2nd Vice President of the U.S. He serves as an antagonist for the majority of Act 2.
In a second cabinet meeting, Jefferson and Hamilton debate on whether the United States should assist the French in their revolution. Jefferson believed they should keep to their word as they promised in the Battle of Yorktown, however, Hamilton thought they should go back on their oath and restrain from giving them military support; once again, Washington ultimately agrees with Hamilton ("Cabinet Battle #2"). This leads to Jefferson, along with Madison and Burr, to become indignant about the unwavering support Hamilton received from President George Washington and the three plotted to ruin Hamilton's political image ("Washington On Your Side").
The three men find the transactions between Hamilton and James Reynolds, and, not knowing Hamilton and being blackmailed by Reynolds and thinking Hamilton had stolen money from the government, Jefferson confronts Hamilton with the amounts. Hamilton reveals to his affair that led to the blackmail and that it was his own money but did not believe Jefferson and the other men would keep it to themselves ("We Know"). However, Jefferson is taken aback as Hamilton goes further as to publish the affair in a public document to evade dishonor but destroy his private reputation in the process ("The Reynolds Pamphlet").
The year is 1800, and Adams drops out of the presidential election. The votes are narrowed onto Jefferson and Aaron Burr; Jefferson is surprised as Hamilton publicly promotes him and gives Jefferson his vote, though the two have never agreed, and effectively ruins Burr's chance at the election in the process. Jefferson then wins the Election of 1800 ("The Election of 1800").
Jefferson's last appearance is in the final song, "Who Lives, Who Dies, Who Tells Your Story", when he admits that "[Hamilton's] financial system is a work of genius" after he has tried undoing it on several occasions.